31位国际学术同仁声援肖传国医生的公开信
Posted by: mendel
Date: September 30, 2010 04:41AM
Open letter in support of Chuan-Guo Xiao, MFile Format: PDF/Adobe Acrobat
September 29, 2010
To all:
We have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years. He is an internationally respected surgeon-scientist who has made major advances in the development of neuroregeneration to restore voiding and bowel function. Dr. Xiao performed groundbreaking animal research in the United States, demonstrating that a motor nerve that innervates the leg can be used to reinnervate the bladder and bowel. This reinnervation allows for development of a reflex to initiate bladder function. The results of his studies were published in peer-reviewed journals and other scientists have replicated Xiao’s findings confirming these results.
Dr. Xiao eventually took the courageous step of moving from animal research to human studies and began performing the rerouting procedure on patients with spinal cord injury and spina bifida in China.
Neurogenic bladder is life threatening in China due to a lack of both antimuscarinics and intermittent catheterization, and lessening the complications of neurogenic bladder would be considered a lifesaving success. Patients with neurogenic bladder and bowel suffer greatly and endure a host of issues such as urinary retention, incontinence, recurrent infections, renal insufficiency, fecal incontinence, constipation, and poor quality of life. For a procedure as complicated as nerve rerouting requiring nerve regeneration, one cannot expect normalization of bladder and bowel function to be the definition of success. What is important is that the benefits outweigh the risks of the procedure.
Dr. Xiao published his clinical results in peer-reviewed journals and was twice honored by the Jack Lapides Essay Contest, one of the most respected international awards given to scientists who make major contributions to the field of neurourology. In 2008, he was named the Kelm Hjalmas Memorial Lecturer from the International Children’s Continence Society for his scientific achievements. Many of us have traveled to China to examine patients treated by Dr. Xiao and/or have been trained by him in the nerve rerouting surgery he invented. Dr. Xiao is a very skilled surgeon who is passionate about patient care and works tirelessly to train physicians around the world in performing his nerve rerouting procedure.
In the United States, an independent and very rigorous pilot research trial was performed to test the safety and efficacy of this procedure. The one-year results were recently published in the Journal of Urology. At the 12-month follow-up visit, a cutaneous to bladder reflex was found in 7 of 9 spina bifida patients, confirming that rerouting does occur. This finding by itself is remarkable and Dr. Xiao should be commended. In addition, a number of patients demonstrated improvement in bladder and bowel function, which has continued to improve with longer patient follow-up. The 36-month results are currently being analyzed and will be reported in the near future. The pilot data was supportive of Dr. Xiao’s procedure, and now an NIH sponsored clinical trial is being conducted to further study lumbar to sacral nerve rerouting in spina bifida patients. In addition, similar procedures have been done worldwide, with Dr. Xiao helping to mentor the surgeons at each site.
The Chinese people and government should be proud of Dr. Xiao for his dedication to his patients, his scientific achievements, and his willingness to train doctors around the world how to perform his surgery. The International scientific community was shocked to hear of Dr. Xiao’s arrest. Those of us who know Dr. Xiao well find it difficult to believe that he is involved in these attacks.
Dr. Xiao is a compassionate man who is respected worldwide for his integrity and his innovative scientific contributions to society. We implore the Chinese government and authorities to treat Dr. Xiao fairly and to protect his human rights as these charges are investigated. Please strongly consider Dr. Xiao’s scientific and humanitarian contributions to the world as facts are gathered in this case.
Sincerely,
Kenneth M. Peters, MD
Professor and Chairman of Urology
Beaumont Hospital
Royal Oak, Michigan
Jack S. Elder, M.D.
Chief of Urology, Henry Ford Health System
Associate Director, Vattikuti Urology Institute
Department of Urology, Children's Hospital of Michigan
Clinical Professor of Urology, Case School of Medicine
Edwin A. Smith M.D.
Assistant Clinical Professor of Urology
Emory University School of Medicine
Atlanta, Georgia
Kevin M. Feber, MD, FAAP
Board Certified in Pediatric Urology
Comprehensive Urology
William Beaumont Children's Hospital
Ananias C. Diokno, M.D., F.A.C.S.Executive Vice President & CMOBeaumont HospitalRoyal Oak, Michigan 48073 USA
Juan José de Benito
Urologist
Hospital Nacional de Clínicas
Córdoba, Argentina.
William E. Nantau B.Sc., CNIMClinical ManagerClinical Neurophysiology DepartmentBeaumont Hospital Royal Oak
Evan J Kass MD,FACS,FAAPChief, Division of Pediatric UrologyBeaumont Childrens HospitalProfessor of Urology, Oakland University-William Beaumont School of Medicine
Jacques Corcos MD.Professor of Urology, McGill UniversityGeneral Secretary of the International Continence SocietyJewish General hospital3755 Cote Ste-CatherineMontreal, Quebec, Canada H3T 1E2
Jose Gonzalez, M.D.
Department of Urology
Beaumont Hospital
Royal Oak, Michigan
Christopher Payne, MD
Associate Professor of Urology
Stanford University Medical School
Stanford, CA 94305-5118
Kenneth I. Glassberg, MD
Director, Division of Pediatric Urology
Morgan Stanley Children's Hospital of New York-Presbyterian
Professor of Urology, Columbia University
College of Physicians and Surgeons
3959 Broadway, CHN 1118
Earl Y. Cheng, MD
Associate Professor of Urology
Children’s Memorial Hospital
Chicago, Illinois
Darius J. Bagli, MDCM
Professor of Surgery
Senior Associate Scientist
Director of Urology Research
Divisions of Urology and
Developmental & Stem Cell Biology
The Hospital For Sick Children
Institute of Medical Science
University of Toronto
Henri B. LOTTMANN, MD, FEBU, FEBPS, FRCS(england) FEBPU
Paediatric urology unit
Hopital Necker-Enfants-Malades
149, rue de Sèvres
75015 Paris
France
Dr. Amrish Vaidya MS. MCh.Consultant Paediatric Surgeon,Kokilaben Dhirubhai Ambani Hospital,4 Bungalows, Andheri W, Mumbai, India
Marc Cendron, MD
Associate Professor in Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA
Stuart B. Bauer, MD
Associate Director, Neurourology
Professor of Urology
Harvard Medical School
Children’s Hospital Boston
Boston, MA
Edmond T. Gonzales, Jr., MD
Professor of Urology
Baylor College of Medicine
Richard Macchia, MD FACS
SUNY Distinguished Teaching Professor
Cleveland Clinic, Florida
Benjamin Girdler, MD
Urology Center of the Rockies
Fort Collins, Colorado
William C. de Groat, Ph.D.
Professor of Pharmacology
University of Pittsburgh
Michael R. Ruggieri, Sr., Ph.D.
Director of Urologic Research
Temple University School of Medicine
Stanley J Kogan MDChief, Pediatric UrologyChildren's Hospital at MontefioreBronx NY USA
Anthony Caldamone, MD
University Urologic Associates, Inc.2 Dudley St Ste 185Providence, RI 02905
Yves Homsy MD, FRCSC, FAAP Clinical Professor of Urological Surgery and Pediatrics University of South Florida Children's Urology Group 5507 E. Longboat Blvd Tampa FL 33615
Dr. Enrique Turina
Professor of urology of the National University of Buenos Aires
Chief of section Urology of Instituto de Rehabilitación
Government of Buenos Aires, Argentina.
Dr. Angel Ozón
Urologist of the Instituto de Rehabilitación of Buenos Aires
Dr. Daniel Ekizian
Urologist of Instituto de Rehabilitación.
Professor Dr. med. Karl-Dietrich Sievert
Vice Chair Prof. of Urology, Director - Uro-oncology, Neurourology, Incontinence, & Reconstructive Urology Department of Urology University of Tuebingen D72076 Tuebingen, Germany
Holly Gilmer, MD
Chief of Pediatric Neurosurgery
Beaumont Hospital
Royal Oak, Michigan
Yegappan Lakshmanan, MD
Chief, Pediatric Urology
Children’s Hospital of Michigan